Healthy Aging

Cognitive Super Agers – The Puzzle of Aging Brains That Don’t Act Their Age

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Cognitive Super Agers – The Puzzle of Aging Brains That Don’t Act Their Age about Stem Cell Restore

What if your brain could defy time—staying sharp, quick, and resilient well into your 80s or beyond? While most people experience gradual memory decline as they age, a rare group known as cognitive super-agers seem almost immune to this process. Their brains function like those of people decades younger, and scientists are determined to unlock their secrets.

Could certain habits, lifestyle choices, or even structural brain differences hold the key to lifelong mental sharpness? The research is fascinating—and the insights might help you dementia-proof your own mind.

Key Takeaways

  • Super-agers’ brains resist aging – Studies show that their brains shrink at a much slower rate than those of normal aging adults.
  • Brain structure matters – A thicker cingulate cortex, better-organized white matter, and more Economo neurons contribute to cognitive resilience.
  • Lifestyle plays a role – Lifelong learning, meaningful social connections, and consistent physical activity may support brain health and slow aging.

The Incredible Brains That Stay Young—And How Yours Can, Too

While most research into the aging brain has focused on the glitches that can gum up the cognitive abilities of older brains, some researchers are now concentrating on finding out how the brains of some seniors keep those glitches at bay.

These investigations are analyzing what’s different in the brains of people in their eighties and older who have intellectual capacities that match those of people in their sixties or even younger.

For example, research in Spain recently examined the brains of about five dozen older folks who enjoyed the cognitive abilities of younger people and compared them to about the same number of seniors with normal memories and thinking abilities. When the scientists took a close look at the brains’ white matter in all these individuals (white matter is the brain’s nerve fiber network that distributes neuronal messages in the brain) found that the white matter's structure in the super-agers was better organized for a sharper memory.

The Hidden Advantage That Protects Some Brains from Aging

Meanwhile, researchers at Northwestern have uncovered what they call a “brain signature” in the structure of brains that resists aging the way Superman’s super skull resists a crowbar to the head. Their scans show that the brains that don’t age much have a thicker cingulate cortex- a part of the brain that shuffles incoming information that’s vital for attention span, memory recall, and control of your thought processes.

In other words, a thicker cingulate cortex seems to be a kind of bulletproof vest that repels aging’s memory-draining bullets.

Plus, there’s more: the Northwestern scientists found that the high-performing brains possess a bigger collection of what are called Economo neurons (spindle neurons) -- brain cells that take part in supporting emotional intelligence and awareness of how to carry on social interactions.

Remarkably, this part of the brain in super-ager brains was not only larger in size compared to other seniors, but it was also larger than in people who were in their 50s and 60s!

As for the overall size of the age-resistant brains, the Northwestern researchers discovered they were larger than would be expected during normal aging. Although everyone’s brain shrinks year-to-year, the super-ager brains only lost about one percent of their mass annually while the normal brains lost more than two percent.

How to Train Your Brain to Stay Young—The Science of Super-Agers

While the studies of the super-agers’ brains haven’t pinpointed exactly why these brains don’t wear down as do the brains in other people, the researchers believe they support several theories about how lifestyle habits can protect against aging.

For instance, Yaakov Stern, PhD, a researcher at Columbia University, thinks that pursuing more education and working at a job that demands intellectual engagement can make your brain more aging-resistant.

The first place to start is your diet. It’s always a good idea to eat a brain-boosting anti-inflammatory diet that focuses on foods that stop your brain from shrinking. Then, consider avoiding the high sugar foods and beverages—even alcohol—that can promote brain shrinking.

Another study at Northwestern demonstrates that maintaining “greater levels of positive social relationships” – having a strongly supportive circle of friends and relatives – may help keep your brain bigger and working reliably.

Added to those, many studies now show that keeping up a consistent exercise program, whether it includes walking, running, weight-lifting, or some other physical activity, supports better brain health as you age.

Doing all of these things can give you a better chance of having an age-resistant brain. And they’ll probably make your life a lot more enjoyable too!

Summary

Cognitive super-agers are individuals whose brains remain remarkably sharp well into old age, defying the typical decline seen in their peers. Research suggests that their brains have structural advantages, such as thicker cingulate cortexes and better-organized white matter, which contribute to memory retention and cognitive resilience. Scientists have also found lifestyle patterns that may play a role in preserving brain function, such as intellectual engagement, strong social connections, and regular physical activity. While there’s no single formula for becoming a super-ager, adopting these habits may help protect against cognitive decline.

Frequently Asked Questions

  • What is a cognitive super-ager?
    A cognitive super-ager is an older adult whose brain retains the memory, thinking speed, and cognitive abilities of someone decades younger.
  • What makes super-agers’ brains different?
    Research shows that super-agers have thicker brain regions responsible for memory and focus, better-organized white matter, and a higher number of specialized neurons.
  • Can anyone become a super-ager?
    While genetics may play a role, studies suggest that maintaining intellectual engagement, strong social connections, and physical activity can help protect brain function.
  • Does exercise help with brain aging?
    Yes! Regular physical activity supports brain health by improving circulation, reducing inflammation, and promoting the growth of new brain cells.
  • How does socializing impact brain health?
    Strong relationships and frequent social interactions are linked to larger brain volume and better cognitive function, helping to delay memory decline.
  1. Garo-Pascual M, et al. “Superagers Resist Typical Age-Related White Matter Structural Changes” J Neurosci .2024 Jun 19;44(25) https://pubmed.ncbi.nlm.nih.gov/38684365/
  2. National Institute of Aging Research Highlight, “Cognitive super agers defy typical age-related decline in brainpower” https://www.nia.nih.gov/news/cognitive-super-agers-defy-typical-age-related-decline-brainpower
  3. IBID
  4. Maher AC, et al. “Psychological well-being in elderly adults with extraordinary episodic memory” PLoS One. 2017; 12(10) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653294/
  5. Hayes SM, et al. “Physical Activity Is Positively Associated with Episodic Memory in Aging” J Int Neuropsychol Soc 2015 Nov;21(10):780-90 https://pubmed.ncbi.nlm.nih.gov/26581790/
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